The Emr Lab

Welcome to Emr Lab 2015 copy

The Emr lab studies the regulation of cell signaling pathways by phosphoinositide kinases, vesicle-mediated transport reactions, 
and selective ubiquitin modifications.

The ESCRT Pathway



Global Screening for Novel Endosomal Sorting Factors

novel endosomal sorting factors


Arrestin-Related ART Proteins Regulate Endocytosis by Selective Ubiquitin Modification of PM Proteins



Phosphoinositide Lipid Signaling




Click here for more information…

Print Friendly, PDF & Email

Scott Emr, PhD

Scott D. Emr is the Frank H.T. Rhodes Class of 1956 Professor of Molecular Biology and Genetics and Director of the Weill Institute for Cell and Molecular Biology (Weill Institute). He received his Ph.D. degree in Molecular Genetics from Harvard Medical School in 1981. Prior to joining the faculty at Cornell, he has held positions at the University of California, Berkeley (Miller Research Scholar; 1981-1983), the California Institute of Technology (Assistant and Associate Professor; 1983-1991) and the University of California, San Diego School of Medicine (Distinguished Professor and Investigator in the Howard Hughes Medical Institute; 1991-2007). Dr. Emr counts among his early honors a Searle Scholars Award and an NSF Presidential Young Investigator Award. He has been elected a member of the National Academy of Sciences (2007), the American Academy of Arts and Sciences (2004) and the American Academy of Microbiology (1998). In 2003, he was awarded the Hansen Foundation Gold Medal Prize for elucidating intracellular sorting and transport pathways. In 2007, he was awarded the Avanti Prize for his key contributions in understanding lipid signaling pathways. He has also served as a member of the Advisory Boards for the Pew Scholars Program in Biomedical Sciences and the Searle Scholars Program.

Selected Publications

J Cell Biol: Rsp5 Ubiquitin ligase–mediated quality control system clears membrane proteins mistargeted to the vacuole membrane. Sardana R, Zhu L, Emr SD. (Oct. 2018)

J Cell Biol: Membrane protein recycling from vacuole/lysosome membrane. Suzuki SW, Emr SD. (May 2018)

Elife: ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins. Zhu L, Jorgensen JR, Li M, Chuang YS, Emr SD. (Jun. 2017)

Mol Biol Cell: Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex. Guiney EL, Klecker T, Emr SD. (Dec. 2016)

Elife: ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis. Tang S, Buchkovich NJ, Henne WM, Banjade S, Kim YJ, Emr SD. (Apr. 2016)

Elife: Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments. Tang S, Henne WM, Borbat PJ, Buchkovich NJ, Freed JH, Mao Y, Fromme JC, Emr SD. (Dec. 2015)

J Cell Biol.: Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, Koshi T, Emr SD. (Nov. 2015)

J Cell Biol.: Mdm1/Snx13 is a novel ER–endolysosomal interorganelle tethering protein. Henne WM, Zhu L, Balogi Z, Stefan C, Pleiss JA, Emr SD. (Aug. 2015)

Curr. Opin. in Cell Biol.: Molecular mechanisms of inter-organelle ER-PM contact sites. Henne WM, Liou J, Emr SD. (May 2015)

Mol. Cell: Ubiquitin-dependent lysosomal membrane protein sorting and degradation. Li M, Rong Y, Chuang Y, Peng D, Emr SD. (Jan. 2015)

Dev. Cell: Essential N-Terminal Insertion Motif Anchors the ESCRT-III Filament during MVB Vesicle Formation. Buchkovich NJ, Henne WM, Tang S, Emr SD. (Oct. 2013)

Cold Spring Harb Perspect Biol. Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway. Henne WM, Stenmark H, Emr SD (Sept. 2013)

JBC: The Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2)-dependent Tup1 Conversion (PIPTC) Regulates Metabolic Reprogramming from Glycolysis to Gluconeogenesis. Han BK, Emr SD (July 2013)

Elife: The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress. Zhao Y, MacGurn JA, Liu M, Emr SD (April 2013)

Dev Cell: ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Manford AG, Stefan CJ, Yuan HL, Macgurn JA, Emr SD (Dec. 2012)

Cell: The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices. Henne WM, Buchkovich N, Zhao Y, Emr SD (October 2012)

Cell: TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor. MacGurn JA, Hsu PC, Smolka MB, Emr SD (2011)

Cell: Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites. Stefan CJ, Manford AG, Baird D, Yamada-Hanff J, Mao Y, Emr SD (2011)

Skip to toolbar